泌乳大鼠乳糖合成的日变化及对食物剥夺的反应
Diurnal variation and response to food withdrawal of lactose synthesis in lactating rats.
作者信息
Carrick D T, Kuhn N J
出版信息
Biochem J. 1978 Jul 15;174(1):319-25. doi: 10.1042/bj1740319.
Abstract
- The incorporation of radiolabelled plasma glucose into mammary lactose was used to measure the rate of lactose synthesis in lightly anaesthetized lactating rats. 2. Lactose synthesis showed a diurnal variation with a minimum at 18:00h 3. Food withdrawal for 6h did not affect lactose synthesis in the early morning but greatly decreased it in the afternoon or evening. 4. Plasma glucose, milk sugars and total galactosyltransferase activity (EC 2.4.1.22) did not show the above changes. 5. Measurements of plasma insulin, which varies diurnally, and experiments with injected insulin suggested that variations of insulin within the physiological range do not account for the changes in lactose synthesis described.
摘要
- 利用放射性标记的血浆葡萄糖掺入乳腺乳糖的情况来测量轻度麻醉的泌乳大鼠的乳糖合成速率。2. 乳糖合成呈现昼夜变化，在18:00时最低。3. 禁食6小时对清晨的乳糖合成没有影响，但在下午或傍晚则使其大幅下降。4. 血浆葡萄糖、乳中糖类和总半乳糖基转移酶活性（EC 2.4.1.22）未表现出上述变化。5. 对昼夜变化的血浆胰岛素进行测量以及注射胰岛素的实验表明，生理范围内胰岛素的变化并不能解释所描述的乳糖合成变化。
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