Nomura Y, Segawa T
Eur J Pharmacol. 1978 Jul 15;50(2):153-6. doi: 10.1016/0014-2999(78)90012-2.
Apomorphine-induced locomotor stimulation was investigated in the developing rat following injection with 6-hydroxydopa at birth. Treatment with 6-hydroxydopa potentiated locomotor responsiveness to apomorphine in the 20-day-old rat. The 6-hydroxydopa-treated animal at 30 days, however, was less sensitive to the drug than was the control. Apomorphine again elicited more locomotor stimulation in 6-hydroxydopa-treated animals than in the controls on day 50. These results suggest that the altered sensitivity of dopamine receptors induced with 6-hydroxydopa, is influenced by the onset of activity of other "inhibitory" neurons on day 30.
研究了出生时注射6-羟基多巴胺的发育中大鼠对阿扑吗啡诱导的运动刺激反应。6-羟基多巴胺处理增强了20日龄大鼠对阿扑吗啡的运动反应性。然而，30日龄经6-羟基多巴胺处理的动物对该药物的敏感性低于对照组。在第50天，阿扑吗啡再次引起经6-羟基多巴胺处理的动物比对照组更多的运动刺激。这些结果表明，6-羟基多巴胺诱导的多巴胺受体敏感性改变，受到30日龄时其他“抑制性”神经元活动开始的影响。
