Henderson J S
J Exp Med. 1968 Dec 1;128(6):1363-75. doi: 10.1084/jem.128.6.1363.
The mouse mammary tumor MT 296 was used in a further series of experiments on the implantation of tumor, plated out in vivo, from suspensions of individual cells. Lipopolysaccharide from S. typhosa was shown to exert an adjuvator influence. But this adjuvator, an endotoxin, had no direct effect on the suspended tumor cells, unlike the liver preparations previously reported. Lipopolysaccharide from S. typhosa was shown to act on the host. It made the host's connective tissue expanses more susceptible to successful implantation by the tumor cells. It did this only if present at the time these connective tissue expanses were split. The increased susceptibility, caused by splitting the connective tissue expanses in the presence of lipopolysaccharide, declined quickly after 24 hr. The structural changes wrought upon the connective tissues by splitting them in the presence of lipopolysaccharide are described. They show kinship to a Schwartzman reaction of the local type. Their possible role in the adjuvator effect on the plating of single cell suspensions of this tumor is discussed.
小鼠乳腺肿瘤MT 296被用于一系列进一步的实验，这些实验是关于将单个细胞悬液在体内接种肿瘤。已证明伤寒沙门氏菌的脂多糖具有佐剂作用。但这种作为内毒素的佐剂，与先前报道的肝脏制剂不同，对悬浮的肿瘤细胞没有直接作用。已证明伤寒沙门氏菌的脂多糖作用于宿主。它使宿主的结缔组织区域更容易被肿瘤细胞成功植入。只有在这些结缔组织区域被分开时存在脂多糖，才会出现这种情况。在脂多糖存在下通过分开结缔组织区域引起的易感性增加，在24小时后迅速下降。描述了在脂多糖存在下通过分开结缔组织而对结缔组织造成的结构变化。它们显示出与局部型施瓦茨曼反应有亲缘关系。讨论了它们在对该肿瘤单细胞悬液接种的佐剂作用中可能发挥的作用。
