Quantitative aspects of the metabolism of 7, 12-dimethylbenz[a]anthracene by liver homogenates from animals of different age, sex and species.

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作者信息

Sims P, Grover P L

出版信息

Biochem Pharmacol. 1968 Sep;17(9):1751-8. doi: 10.1016/0006-2952(68)90090-7.

DOI:10.1016/0006-2952(68)90090-7

PMID:5688263

Abstract

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相似文献

Quantitative aspects of the metabolism of 7, 12-dimethylbenz[a]anthracene by liver homogenates from animals of different age, sex and species.

Biochem Pharmacol. 1968 Sep;17(9):1751-8. doi: 10.1016/0006-2952(68)90090-7.

Studies on the metabolism of 7-methylbenz-[a]anthracene and 7,12-dimethylbenz[1]anthracene and its hydroxymethyl derivatives in rat liver and adrenal homogenates.7-甲基苯并[a]蒽和7,12-二甲基苯并[a]蒽及其羟甲基衍生物在大鼠肝脏和肾上腺匀浆中的代谢研究。

Biochem Pharmacol. 1970 Jul;19(7):2261-75. doi: 10.1016/0006-2952(70)90125-5.

Metabolism of 7,12-dimethylbenz(a)anthracene by hamster liver homogenates.

Xenobiotica. 1974 Sep;4(9):537-48. doi: 10.3109/00498257409052095.

Formation of glutathione conjugates as metabolites of 7,12-dimethylbenz-(a)anthracene by rat-liver homogenates.大鼠肝脏匀浆将7,12-二甲基苯并(a)蒽代谢为谷胱甘肽共轭物的过程。

Biochem Pharmacol. 1973 Jul 15;22(14):1781-91. doi: 10.1016/0006-2952(73)90392-4.

Metabolism of 7-hydroxymethyl-12-methylbenz(a)anthracene-12-14C in vitro.

Biochem Pharmacol. 1969 Mar;18(3):680-2. doi: 10.1016/0006-2952(69)90094-x.

The effect of pretreatment with adrenal-protecting compounds on the metabolism of 7,12-dimethylbenz[a]anthracene and related compounds by rat-liver homogenates.肾上腺保护化合物预处理对大鼠肝脏匀浆代谢7,12-二甲基苯并[a]蒽及相关化合物的影响。

Biochem J. 1967 Aug;104(2):394-403. doi: 10.1042/bj1040394.

Variations dependent on age and diet in the metabolism of 7,12-dimethylbenz[a]-anthracene by rat liver homogenates.

Nature. 1967 Oct 7;216(5110):77-8. doi: 10.1038/216077a0.

[Characteristics of the formation of lipophilic 7,12-dimethylbenz(a)anthracene products in vivo].

Nauchnye Doki Vyss Shkoly Biol Nauki. 1976(8):31-6.

Conversion of carcinogens related to 7,12-dimethylbenz(a)anthracene by rat liver homogenates to the carcinogenic metabolite 7-hydroxymethyl-12-methylbenz(a)anthracene.

Res Commun Chem Pathol Pharmacol. 1974 Oct;9(2):279-89.

The formation of "K-region" epoxides as hepatic microsomal metabolites of 7-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene and their 7-hydroxymethyl derivatives.

Biochem Pharmacol. 1973 Nov 15;22(22):2853-67. doi: 10.1016/0006-2952(73)90152-4.

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Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm.口服苯并[a]芘：了解药代动力学、解毒和后果——Cyp1 基因敲除小鼠品系作为范例。

Mol Pharmacol. 2013 Sep;84(3):304-13. doi: 10.1124/mol.113.086637. Epub 2013 Jun 12.

Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz( )anthracene 8,9-oxide and 10,11-dihydrobenz( )anthracene 8,9-oxide and their metabolism by rat liver preparations.芳香多环烃的环氧衍生物。苯并（）蒽8,9 - 氧化物和10,11 - 二氢苯并（）蒽8,9 - 氧化物的制备及其在大鼠肝脏制剂中的代谢。

Biochem J. 1971 Nov;125(1):159-68. doi: 10.1042/bj1250159.

Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to benzo(a)pyrene and to 7,8- and 9,10-dihydrobenzo(a)pyrene.芳香多环烃的环氧衍生物。与苯并(a)芘以及7,8-和9,10-二氢苯并(a)芘相关的环氧化物的制备与代谢。

Biochem J. 1972 Jun;128(2):265-77. doi: 10.1042/bj1280265.

Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz(a)anthracene.芳香多环烃的环氧衍生物。与7,12-二甲基苯并(a)蒽相关的环氧化物的制备与代谢。

Biochem J. 1973 Feb;131(2):405-13. doi: 10.1042/bj1310405.

The metabolism of 7,12-dimethylbenz (a) anthracene by homogenates of the stomach and small intestine of mice.7,12-二甲基苯并(a)蒽在小鼠胃和小肠匀浆中的代谢情况。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(3):223-30. doi: 10.1007/BF00303567.

Metabolic pathways of 7,12-dimethylbenz[a]anthracene in hepatic microsomes.7,12-二甲基苯并[a]蒽在肝微粒体中的代谢途径。

Proc Natl Acad Sci U S A. 1975 Jul;72(7):2601-5. doi: 10.1073/pnas.72.7.2601.

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