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天然抗肿瘤药物的微生物转化：金黄被孢霉对长春多灵的O-去甲基化作用

Microbial transformations of natural antitumor agents: O-demethylation of vindoline by Sepedonium chrysospermum.

作者信息

Wu G S, Nabih T, Youel L, Peczynska-Czoch W, Rosazza J P

出版信息

Antimicrob Agents Chemother. 1978 Oct;14(4):601-4. doi: 10.1128/AAC.14.4.601.

DOI:10.1128/AAC.14.4.601
PMID:568911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352513/
Abstract

Vindoline (1a) was transformed to O-demethylvindoline (1b) by Sepedonium chrysospermum ATCC 13378 in 33% yield. Thin-layer and high-pressure liquid chromatographic methods distinguished 1b from previously reported microbial metabolites of vindoline. The structural proof of 1b was based on its mass spectral fragmentation pattern and on its chemical and nuclear magnetic resonance spectral properties.

摘要

长春多灵（1a）被金黄隔孢腔菌ATCC 13378转化为去甲氧基长春多灵（1b），产率为33%。薄层色谱法和高压液相色谱法将1b与先前报道的长春多灵微生物代谢产物区分开来。1b的结构确证基于其质谱裂解模式及其化学光谱和核磁共振光谱性质。

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本文引用的文献

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A note on the alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.). II. Catharanthine, lochnericine, vindolinine, and vindoline.长春花生物碱的注释。II. 长春花碱、洛柯新碱、文多灵宁和文多灵。
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Helv Chim Acta. 1973 Jul;56(7):2418-26. doi: 10.1002/hlca.19730560725.
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