通过小牛空肠逆转热带和非热带口炎性腹泻中的叶酸吸收不良。

Reversal of folate malabsorption in tropical and non-tropical sprue by calf jejunum.

作者信息

Baker H, Frank O, Ziffer H, Feingold S, Cintron-Rivera A A

出版信息

Br Med J. 1968 Aug 24;3(5616):472-4. doi: 10.1136/bmj.3.5616.472.

DOI:10.1136/bmj.3.5616.472

PMID:5691146

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1986426/

Abstract

In eight patients with folic acid malabsorption the malabsorption was reversed only when a combination of either 250 mg. of lyophilized human jejunal juice or 5 g. of lyophilized calf jejunum with 5 mg. of synthetic folic acid was fed; calf liver was ineffective. The factors in calf jejunum that re-established folic acid absorption were heat-stable and did not form polyglutamyl folates on previous incubation with folic acid.

摘要

在8例叶酸吸收不良患者中，仅当给予250毫克冻干人空肠液或5克冻干小牛空肠与5毫克合成叶酸的组合时，吸收不良才得到逆转；小牛肝脏无效。小牛空肠中重新建立叶酸吸收的因素是热稳定的，并且在先前与叶酸孵育时不会形成多聚谷氨酰叶酸。