Weiss M H, Craig J R
Bull Los Angeles Neurol Soc. 1978 Mar;43(1):1-5.
The influence of acute ethanolic intoxication on intracranial physical dynamics was assessed in 42 adult cats. Acute ethanolism significantly alters intracranial tissue compliance as determined by the intracranial volume-pressure response. Cerebral vasodilatation, secondary to ethanol administration, appears to be an underlying mechanism, possibly augmented by secondary cerebral edema. Studies of CSF production and absorption as well as osmolar ratio show no changes under conditions of acute ethanol intoxication. The observed decrease in cerebral compliance may well relate to the poor prognosis, in general, of the alcoholic brain that is subjected to trauma.
在42只成年猫身上评估了急性乙醇中毒对颅内物理动力学的影响。急性乙醇中毒通过颅内容量-压力反应测定，显著改变了颅内组织顺应性。乙醇给药继发的脑血管扩张似乎是一种潜在机制，可能因继发性脑水肿而加剧。在急性乙醇中毒情况下，脑脊液生成和吸收以及渗透压比的研究未显示变化。观察到的脑顺应性降低很可能与遭受创伤的酒精性脑总体预后不良有关。
