Wright A D, Walsh C H, Fitzgerald M G, Malins J M
Br Med J. 1979 Jan 6;1(6155):25-7. doi: 10.1136/bmj.1.6155.25.
In a one-year follow-up study the insulin dose in diabetic patients using very pure porcine insulin was compared with that in patients using conventional preparations. The dose of insulin used to obtain diabetic control was reduced by 7% in 108 patients treated solely with very pure porcine insulin from the start of insulin treatment when compared with 108 matched patients who had received conventional insulins. In 117 patients whose treatment had been changed from conventional bovine or bovine-porcine insulin to very pure porcine insulin the dose was reduced by 9%. A further 511 patients receiving conventional insulins were examined for local cutaneous or subcutaneous abnormalities at insulin injection sites. Lipoatrophy was found in 49 of these patients (10%), but not in patients using very pure porcine insulin. The results confirm that very pure porcine insulin reduces the insulin dose needed to maintain diabetic control and may resolve or prevent local reactions such as lipoatrophy. Long-term advantages in reduced antigenicity to insulin and contaminating peptides remain to be established.
在一项为期一年的随访研究中，对使用极纯猪胰岛素的糖尿病患者与使用传统制剂的患者的胰岛素剂量进行了比较。与108名使用传统胰岛素的匹配患者相比，从胰岛素治疗开始就单纯使用极纯猪胰岛素治疗的108名患者，用于控制糖尿病的胰岛素剂量降低了7%。在117名治疗从传统牛胰岛素或牛-猪胰岛素改为极纯猪胰岛素的患者中，剂量降低了9%。另外对511名使用传统胰岛素的患者进行了胰岛素注射部位局部皮肤或皮下异常检查。在这些患者中有49名（10%）发现有脂肪萎缩，但使用极纯猪胰岛素的患者未出现。结果证实，极纯猪胰岛素可减少维持糖尿病控制所需的胰岛素剂量，并可能消除或预防诸如脂肪萎缩等局部反应。胰岛素和污染肽抗原性降低的长期优势仍有待确定。
