Hargis A M, Lee A C, Thomassen R W
J Am Vet Med Assoc. 1978 Nov 1;173(9):1185-90.
Review of records of 1,680 research colony Beagles revealed proliferative and neoplastic lesions in the nasal or temporal limbal conjunctiva of 8 male and 6 famale dogs. The mean age at observation was 5.2 years. The lesions ranged from acanthosis and squamous cell carcinoma of the conjunctival epithelium to vascular ectasia, hemangioma, and invasive hemangiosarcoma of the underlying lamina propria. The lesions developed under circumstances that suggested solar radiation was involved in the pathogenesis.
对1680只实验用比格犬的记录进行回顾后发现,8只雄性和6只雌性犬的鼻侧或颞侧角膜缘结膜出现了增生性和肿瘤性病变。观察时的平均年龄为5.2岁。病变范围从结膜上皮的棘皮症和鳞状细胞癌到深层固有层的血管扩张、血管瘤和浸润性血管肉瘤。这些病变是在提示太阳辐射参与发病机制的情况下发生的。