前列腺素D2是鸡尿酸盐关节炎急性炎性渗出物中占主导地位的前列腺素。
Prostaglandin D2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in the chicken.
作者信息
Anhut H, Brune K, Frölich J C, Peskar B A
出版信息
Br J Pharmacol. 1979 Mar;65(3):357-9. doi: 10.1111/j.1476-5381.1979.tb07837.x.
Abstract
An acute inflammation was elicited in intertarsal joints of chicken by injection of urate crystals. Inflammatory exudates recovered at different times were assayed for prostaglandin D2(PGD2)E2 and F2 alpha and thromboxane B2 content by specific radioimmunoassays. We found that PGD2 was the prevailing prostaglandin reaching concentrations up to 10 times in excess of PGE2. This finding was confirmed by gas chromatography-mass spectrometry. It is concluded that PGD2 should be considered as a possible mediator of acute inflammation.
摘要
通过注射尿酸盐晶体在鸡的跗间关节引发急性炎症。对在不同时间收集的炎性渗出物，采用特异性放射免疫分析法检测前列腺素D2（PGD2）、E2和F2α以及血栓素B2的含量。我们发现PGD2是主要的前列腺素，其浓度高达PGE2的10倍以上。这一发现通过气相色谱-质谱法得到了证实。结论是PGD2应被视为急性炎症的一种可能介质。
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