延髓腹侧面上对乙酰胆碱和尼古丁的呼吸与循环反应的 topography 。 （注：topography 可译为“局部解剖图；地形学；局部解剖学”等，这里具体含义需结合上下文确定）
Topography of the respiratory and circulatory responses to acetylcholine and nicotine on the ventral surface of the medulla oblongata.
作者信息
Dev N B, Loeschcke H H
出版信息
Pflugers Arch. 1979 Feb 14;379(1):19-27. doi: 10.1007/BF00622900.
PMID:571101
Abstract
- Acetylcholine and nicotine were superfused on the ventral medullary surface between the ponto-medullary border and C1 in anaesthetized cats in order to determine the topical distribution of their actions on respiration and circulation. 2. Acetylcholine (10(-4) g . ml-1 = 5.5 . 10(-4) mMol . ml-1) produced an increase in respiration and a lowering of blood pressure. The magnitude and the time course of the responses varied according to the points of superfusion on the surface. 3. Nicotine (10(-4) g . ml-1 = 6.2 . 10(-4) mMol . ml-1) elicited hyperventilation and more often an increase in arterial pressure on unilateral superfusion of the surface. In some cases, however, a drop in blood pressure was also observed. 4. The responsive regions of the surface on which nicotine acted and elicited hyperventilation, bear a close resemblance to the regions responsive to acetylcholine. 5. The topographical distribution of the respiratory effects elicited by the above-mentioned drugs were similar to the distribution of the responses to changes in pH on the ventral medullary surface or to electrical stimulation. 6. Procaine (2 . 10(-2) g . ml-1 = 7.3 . 10(-2) mMol . ml-1) applied bilaterally in the intermediate zone (S) caused profound inhibition of respiration and of arterial pressure. Procaine at this concentration also inhibited respiratory hyperventilation caused by nicotine (10(-4) g . ml-1 = 6.2 . 10(-4) mMol . ml-1) applied to the caudal and rostral areas.
摘要
- 将乙酰胆碱和尼古丁灌注到麻醉猫脑桥 - 延髓边界与C1之间的延髓腹侧面，以确定它们对呼吸和循环作用的局部分布。2. 乙酰胆碱（10⁻⁴g·ml⁻¹ = 5.5·10⁻⁴mmol·ml⁻¹）可使呼吸增强，血压降低。反应的幅度和时程因表面灌注点而异。3. 尼古丁（10⁻⁴g·ml⁻¹ = 6.2·10⁻⁴mmol·ml⁻¹）单侧灌注到表面时会引发过度通气，且更常使动脉压升高。然而，在某些情况下也观察到血压下降。4. 尼古丁作用并引发过度通气的表面反应区域与对乙酰胆碱反应的区域非常相似。5. 上述药物引发的呼吸效应的地形分布与延髓腹侧面pH变化反应或电刺激反应的分布相似。6. 在中间区（S）双侧应用普鲁卡因（2·10⁻²g·ml⁻¹ = 7.3·10⁻²mmol·ml⁻¹）会导致呼吸和动脉压的深度抑制。该浓度的普鲁卡因也能抑制尼古丁（10⁻⁴g·ml⁻¹ = 6.2·10⁻⁴mmol·ml⁻¹）应用于尾侧和头侧区域所引起的呼吸过度通气。
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