Casar C, Díaz A, Ceruti E, Danus O, Vildosola C
Bol Med Hosp Infant Mex. 1979 Jul-Aug;36(4):653-63.
The study comprised 458 infants complaining of recurrent obstructive bronchitis from the clinical, chest X-rays and gastroesophageal reflux investigation view points. Spontaneous radiological reflux was found in 49.1% of the patients, although a history of vomiting was present only in 26.6%. In infants with positive radiological reflux, manometrics showed a shorter gastroesophageal sphincter and with lesser pressures than a group of normal infants. With medical treatment of the reflux, remission of the respiratory symptoms was seen in 63.5% of the patients. In a group of infants treated, control X-rays, and manometrics were practiced at the end of the medical treatment showing significant improvement of pressure and length of the gastroesophageal sphincter. The long-term follow-up in infants showing failure of the medical treatment, bronchial asthma appeared in 56.6%.
该研究纳入了458例从临床、胸部X线及胃食管反流检查角度来看患有复发性阻塞性支气管炎的婴儿。49.1%的患者存在自发性放射学反流，尽管仅有26.6%的患者有呕吐史。在放射学反流阳性的婴儿中，食管测压显示其胃食管括约肌较短，压力低于一组正常婴儿。经反流药物治疗后，63.5%的患者呼吸道症状缓解。在一组接受治疗的婴儿中，治疗结束时进行了对照X线检查和食管测压，结果显示胃食管括约肌的压力和长度有显著改善。在药物治疗失败的婴儿长期随访中，56.6%出现了支气管哮喘。
