Oakley G D, McGarry K, Limb D G, Oakley C M
Br Med J. 1979 Jun 30;1(6180):1749-50. doi: 10.1136/bmj.1.6180.1749.
The outcome of 54 pregnancies in 23 patients with hypertrophic cardiomyopathy was analysed. No mother or infant died in the perinatal period. Six patients developed dyspnoea requiring treatment with diuretics. Beta-adrenergic blocking drugs were given in 18 pregnancies and three of the infants in this were small for dates and in two fetal bradycardia occurred. The results comfirmed that pregnancy is safe in patients with hypertrophic cardiomyopathy. A flexible approach should be adopted towards administering beta-adrenergic blocking drugs to pregnant women with hypertrophic cardiomyopathy. Many such patients do well without these drugs and can thus avoid the potential hazards--namely, small-for-dates babies and fetal bradycardia--that are associated with them.
对23例肥厚型心肌病患者的54次妊娠结局进行了分析。围产期无母婴死亡。6例患者出现呼吸困难，需要使用利尿剂治疗。18例妊娠患者使用了β-肾上腺素能阻滞剂，其中3例婴儿小于孕周，2例出现胎儿心动过缓。结果证实，肥厚型心肌病患者妊娠是安全的。对于肥厚型心肌病孕妇使用β-肾上腺素能阻滞剂应采取灵活的方法。许多此类患者在不使用这些药物的情况下情况良好，因此可以避免与之相关的潜在危害，即小于孕周的婴儿和胎儿心动过缓。
