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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Matsumori A, Hirose K, Wakabayashi A, Kawai C, Nabeya N, Sakurami T, Tsuji K

Jpn Circ J. 1979 May;43(5):445-9. doi: 10.1253/jcj.43.445.

HLA antigens were determined in 30 Japanese patients with hypertrophic cardiomyopathy. Several antigens were more common in patients compared with controls, but statistically significant differences were not evidenced. In families one and two, six of seven kindred who inherited HLA-A9 and B7 had the disease. None of five kindred lacking HLA-B7 showed evidence of the disease. In families three and four, affecting family members had HLA-A2 and BW-35. Our finding suggest that the HLA system may play some role in the pathogenesis of hypertrophic cardiomyopathy with familial occurrence. 2. Twenty patients with rheumatic valvular heart disease were also studied. There was no significant difference in frequencies of HLA antigens between patients and controls.

对30名日本肥厚型心肌病患者进行了HLA抗原检测。与对照组相比，部分抗原在患者中更为常见，但未发现统计学上的显著差异。在家族一和家族二中，7个遗传了HLA - A9和B7的亲属中有6人患有该病。5个缺乏HLA - B7的亲属均未表现出该病迹象。在家族三和家族四中，患病家庭成员具有HLA - A2和BW - 35。我们的研究结果表明，HLA系统可能在家族性肥厚型心肌病的发病机制中发挥一定作用。2. 还对20名风湿性心脏瓣膜病患者进行了研究。患者与对照组之间HLA抗原频率无显著差异。

Matsumori A, Hirose K, Wakabayashi A, Kawai C, Nabeya N, Sakurami T, Tsuji K

Jpn Circ J. 1979 May;43(5):445-9. doi: 10.1253/jcj.43.445.

HLA antigens were determined in 30 Japanese patients with hypertrophic cardiomyopathy. Several antigens were more common in patients compared with controls, but statistically significant differences were not evidenced. In families one and two, six of seven kindred who inherited HLA-A9 and B7 had the disease. None of five kindred lacking HLA-B7 showed evidence of the disease. In families three and four, affecting family members had HLA-A2 and BW-35. Our finding suggest that the HLA system may play some role in the pathogenesis of hypertrophic cardiomyopathy with familial occurrence. 2. Twenty patients with rheumatic valvular heart disease were also studied. There was no significant difference in frequencies of HLA antigens between patients and controls.

对30名日本肥厚型心肌病患者进行了HLA抗原检测。与对照组相比，部分抗原在患者中更为常见，但未发现统计学上的显著差异。在家族一和家族二中，7个遗传了HLA - A9和B7的亲属中有6人患有该病。5个缺乏HLA - B7的亲属均未表现出该病迹象。在家族三和家族四中，患病家庭成员具有HLA - A2和BW - 35。我们的研究结果表明，HLA系统可能在家族性肥厚型心肌病的发病机制中发挥一定作用。2. 还对20名风湿性心脏瓣膜病患者进行了研究。患者与对照组之间HLA抗原频率无显著差异。