Matsumori A, Kawai C, Wakabayashi A, Terasaki P I, Park M S, Sakurami T, Ueno Y
Am Heart J. 1981 Jan;101(1):14-6. doi: 10.1016/0002-8703(81)90377-x.
To determine the association of histocompatibility (HLA) genes in patients with hypertrophic cardiomyopathy, we determined HLA-A, HLA-B, HLA-C, and HLA-DR specificities in 33 Japanese patients (15 with the obstructive type off hypertrophic cardiomyopathy, and 18 with the nonobstructive type). HLA-DRW4 was found in 73% of patients with hypertrophic obstructive cardiomyopathy, as compared to 33% of 144 normal controls (p < 0.005). HLA-DRW4 occurred in 33% of those with hypertrophic nonobstructive cardiomyopathy, and there was no significant difference as compared with controls. Thus, hypertrophic obstructive cardiomyopathy is associated with genes in the HLA-DR region and immunogenetic factors linked to HLA appear to play a role in the pathogenesis. This work is the first attempt at demonstration of HLA-DR antigen in hypertrophic cardiomyopathy.
为了确定肥厚型心肌病患者组织相容性（HLA）基因之间的关联，我们测定了33例日本患者（15例梗阻性肥厚型心肌病患者和18例非梗阻性肥厚型心肌病患者）的HLA - A、HLA - B、HLA - C和HLA - DR特异性。在梗阻性肥厚型心肌病患者中，73%发现有HLA - DRW4，相比之下，144名正常对照者中有33%发现有HLA - DRW4（p < 0.005）。在非梗阻性肥厚型心肌病患者中，33%出现HLA - DRW4，与对照者相比无显著差异。因此，梗阻性肥厚型心肌病与HLA - DR区域的基因相关，与HLA相关的免疫遗传因素似乎在发病机制中起作用。这项工作是首次尝试在肥厚型心肌病中证明HLA - DR抗原。
