Bundza A, Lowden J A, Charlton K M
Vet Pathol. 1979 Sep;16(5):530-8. doi: 10.1177/030098587901600504.
A 5-month-old minature Poodle dog had widespread cytoplasmic vacuolation of neurons in the central nervous system and foamy macrophages in the lung, spleen, renal lymph node, liver, adrenal gland and intestine. Concentric membranous cytoplasmic inclusions were seen in the neurons of the central nervous system by electron microscopy. There was no sphingomyelinase in the brain tissue. Sphingomyelin and cholesterol were increased in brain, kidney and liver. A diagnosis of Niemann-Pick Disease was based on absence of sphingomyelinase activity, as well as on histologic, histochemical and chemical findings.
一只5个月大的迷你贵宾犬，其中枢神经系统的神经元出现广泛的细胞质空泡化，肺、脾、肾淋巴结、肝、肾上腺和肠道出现泡沫状巨噬细胞。电子显微镜检查发现中枢神经系统的神经元中有同心膜状细胞质内含物。脑组织中没有鞘磷脂酶。脑、肾和肝中的鞘磷脂和胆固醇增加。基于鞘磷脂酶活性的缺乏以及组织学、组织化学和化学检查结果，诊断为尼曼-匹克病。
