Szanto J, Lillis W G, Brown W E, Sutphin C F, Maplesden D C
Am J Vet Res. 1979 May;40(5):673-5.
The new taeniacidal antibiotic S15-1 (SQ 21,704) was evaluated against naturally occuring infections of Taenia pisiformis in 53 dogs, Dipylidium caninum in 35 dogs, T taeniaformis in 18 cats, and D caninum in 33 cats. It all instances, the compound was administered in gelatine capsules in a single oral dose. The doses tested were between and 200 mg/kg of body weight in dogs and between 15 and 45 mg/kg in cats. In dogs, doses of 25 mg/kg and greater were 100% effective against T pisiformis, whereas a dose of 50 mg/kg was necessary to clear D caninum. In cats, a single oral dose of 22.5 mg/kg was 100% efficacious against T taeniaeformis, and a single dose of 45 mg/kg (the largest dose tested) clearly seven of eight cats of D caninum. The efficacy was limited to tapeworms only; there was no efficacy against nematodes. The antibiotic was well tolerated by both species with no drug-related vomiting or other side-effects observed.
新型杀绦虫抗生素S15 - 1（SQ 21,704）针对53只犬的自然感染豆状带绦虫、35只犬的犬复孔绦虫、18只猫的泡状带绦虫以及33只猫的犬复孔绦虫进行了评估。在所有情况下，该化合物均以明胶胶囊形式单次口服给药。测试的剂量在犬中为每千克体重10至200毫克，在猫中为每千克体重15至45毫克。在犬中，25毫克/千克及以上的剂量对豆状带绦虫的有效率为100%，而清除犬复孔绦虫则需要50毫克/千克的剂量。在猫中，单次口服22.5毫克/千克的剂量对泡状带绦虫的有效率为100%，单次45毫克/千克（测试的最大剂量）使8只感染犬复孔绦虫的猫中有7只绦虫被清除。疗效仅限于绦虫；对线虫无效。两种动物对该抗生素耐受性良好，未观察到与药物相关的呕吐或其他副作用。
