Cruthers L R, Linkenheimer W H, Maplesden D C
Am J Vet Res. 1979 May;40(5):676-8.
The streptothrinin antibiotics SQ 21,704 was evaluated against naturally occurring Taenia pisiformis and Dipylidium caninum infections in dogs when they were given at a dose level of 37.5 mg/kg of body weight in four different rations: loaf-type canned meat; chunk-type canned meat; dry (gravy-type) meal; and dry (pelleted) meal. The SQ 21,704 was 100% efficacious against both T pisiformis and D caninum infections when given with the chunk, gravy, and pelleted rations. When given with the loaf-type canned meat, it was 100% effective against T pisiformis and 60% efficacious against D caninum. The SQ 21,704 was effective against both tapeworm species when given orally as a liquid at a dose level of 37.5 mg/kg, formulated as an aqueous suspension containing 94 mg of activity per milliter. The SQ 21,704 was also tested in dogs when given orally in gelatin capsules at a dose level of 37.5 mg/kg without fasting, and was 100% efficacious against both tapeworm species. The results of a comparative taeniacidal study demonstrated that SQ 21,704 was 100% effective in removing both T pisiformis and D caninum when administered orally at a dose level of 37.5 mg/kg, whereas niclosamide and bunamidine hydrochloride were only partially effective at their recommended dose levels. One of five dogs treated with niclosamide at a dose level of 157 mg/kg was positive at necropsy, giving an orally efficacy of 80%. Three of five dogs treated with bunamidine hydrochloride at a dose level of 49 mg/kg were positive at necropsy, giving an overall efficacy of 40%.
对链丝菌素类抗生素SQ 21,704进行了评估，观察其对犬自然感染的豆状带绦虫和犬复孔绦虫的作用，给药剂量为37.5毫克/千克体重，分别添加于四种不同日粮中：面包型罐装肉；块状罐装肉；干（肉汁型）饲料；干（颗粒状）饲料。当与块状、肉汁型和颗粒状日粮一起给药时，SQ 21,704对豆状带绦虫和犬复孔绦虫感染的疗效均达100%。当与面包型罐装肉一起给药时，它对豆状带绦虫的疗效为100%，对犬复孔绦虫的疗效为60%。当将SQ 21,704配制成每毫升含94毫克活性成分的水悬浮液，以37.5毫克/千克的剂量口服给药时，对两种绦虫均有效。还对犬进行了测试，将SQ 21,704装入明胶胶囊中，以37.5毫克/千克的剂量口服给药，无需禁食，对两种绦虫的疗效均达100%。一项比较杀绦虫研究的结果表明，当以37.5毫克/千克的剂量口服给药时，SQ 21,704对清除豆状带绦虫和犬复孔绦虫均有100%的效果，而氯硝柳胺和盐酸丁萘脒在其推荐剂量水平时仅部分有效。五只犬以157毫克/千克的剂量接受氯硝柳胺治疗，其中一只在尸检时呈阳性，口服疗效为80%。五只犬以49毫克/千克的剂量接受盐酸丁萘脒治疗，其中三只在尸检时呈阳性，总体疗效为40%。
