Balkwill F R, Hogg N
J Immunol. 1979 Oct;123(4):1451-6.
Approximately 40% of the cells in human early lactation milk possessed the characteristics of macrophages, being adherent, phagocytic, alpha napthyl acetate esterase positive, and possessing C3b and Fc receptors. These cells were also cytostatic for MDA 157, a cell line derived from a pleural effusion of human breast cancer, and HEL 23, a strain of human fetal lung fibroblasts. Investigations into the cytostatic phenomenon indicated that the cytostasis could not be mediated by macrophage-conditioned medium and that very close contact between breast milk macrophages and target cells was required. Cytostasis was not fully effective until 18 hr after the initial interaction between macrophages and target cells.
人类初乳中约40%的细胞具有巨噬细胞的特征，即具有黏附性、吞噬性、α萘乙酸酯酶呈阳性，且拥有C3b和Fc受体。这些细胞对MDA 157（一种源自人乳腺癌胸腔积液的细胞系）和HEL 23（一种人胎儿肺成纤维细胞株）也具有细胞抑制作用。对这种细胞抑制现象的研究表明，细胞抑制作用不能由巨噬细胞条件培养基介导，母乳巨噬细胞与靶细胞之间需要非常紧密的接触。在巨噬细胞与靶细胞初次相互作用18小时后，细胞抑制作用才完全有效。
