Cabilly S, Gallily R
Immunology. 1981 Jan;42(1):149-55.
Artificial binding of mouse peritoneal macrophages to syngeneic embryonic fibroblasts by means of rabbit anti-mouse anti-macrophage serum or Con-canavalin A inhibited the proliferation of syngeneic target cells without destroying them. It is suggested that an intimate membranal contact between macrophages and target cells triggered cytostasis, whereas cytotoxicity requires an additional step of foreign recognition.
通过兔抗小鼠抗巨噬细胞血清或伴刀豆球蛋白A使小鼠腹腔巨噬细胞与同基因胚胎成纤维细胞人工结合,可抑制同基因靶细胞的增殖而不破坏它们。这表明巨噬细胞与靶细胞之间紧密的膜接触引发了细胞停滞,而细胞毒性则需要额外的外来识别步骤。