牛奶不耐受儿童的胃功能受损。
Impaired gastric function in children with cow's milk intolerance.
作者信息
Kokkonen J, Similä S, Herva R
出版信息
Eur J Pediatr. 1979 Sep;132(1):1-6. doi: 10.1007/BF00443197.
Eight infants with cow's milk intolerance (CMI) were studied for basal and maximal gastric acid secretion and the fasting serum gastrin level. All these patients had clinical malabsorption. Jejunal biopsies revealed subtotal villous atrophy in six children and slight changes in the remaining two. The mean maximal acid secretion in the infants with CMI was significantly decreased being 85 +/- 78 mumol/h/kg (mean +/- SD), as compared with a control group of the same age with a corresponding value of 233 +/- 66 mumol/h/kg. The fasting serum gastrin level was elevated, being 104 +/- 116 pmol/l in the study group and 37 +/- 10 in the controls. Three infants with CMI underwent gastric biopsy. Marked changes with epithelial degeneration and prominent cellularity in the lamina propria were seen in two patients. The injury was most severe in the antrum of the stomach. When these patients with CMI were treated with human or soy milk, the maximal acid secretion returned normal in six months.
对8例牛奶不耐受（CMI）婴儿进行了基础胃酸分泌、最大胃酸分泌及空腹血清胃泌素水平的研究。所有这些患儿均有临床吸收不良表现。空肠活检显示，6例患儿有部分绒毛萎缩，其余2例有轻微改变。CMI婴儿的平均最大胃酸分泌显著降低，为85±78μmol/h/kg（均值±标准差），而同龄对照组的相应值为233±66μmol/h/kg。空腹血清胃泌素水平升高，研究组为104±116pmol/L，对照组为37±10pmol/L。3例CMI婴儿接受了胃活检。2例患者可见明显改变，表现为上皮变性和固有层细胞增多。胃窦部损伤最为严重。这些CMI患儿接受人乳或豆奶治疗后，6个月内最大胃酸分泌恢复正常。
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