Matveev A B, Vereina T L, Kudriashov V M
Farmakol Toksikol. 1979 Nov-Dec;42(6):639-42.
It was shown in experiments on mice administered the alkylating agent BCNU (1,3-bis/2-chlorethyl/-I-nitrosourea) at a dose of 20 mg/kg 48 or 72 hours following immunization wtih sheep red cells that kinetics of producing antibody-forming cells assumes a wave-like pattern with a sharp alternation of rises and falls in the number of antibody inducers. Analysis of the data obtained allowed a conclusion that BCNU does not affect the recruitment -- transformation of the precursor cells to antibody-forming cells.
在给小鼠注射剂量为20毫克/千克的烷化剂BCNU（1,3-双（2-氯乙基）-1-亚硝基脲）的实验中发现，在用绵羊红细胞免疫后48或72小时，产生抗体形成细胞的动力学呈现出波浪状模式，抗体诱导剂数量急剧交替上升和下降。对所得数据的分析得出结论，BCNU不影响前体细胞向抗体形成细胞的募集——转化。
