Rodriguez J A, Borisy G G
Science. 1979 Oct 26;206(4417):463-5. doi: 10.1126/science.574315.
In the brains of newborn rats, about half of the tubulin molecules are modified posttranslationally by the addition of an aromatic amino acid at the carboxyl terminus of the alpha chain. Of the added residues, 96 percent are tyrosine and 4 percent are phenylalanine. After induction of hyperphenylalaninemia, the proportion of tubulin molecules containing carboxyl terminal phenylalanine increases up to eightfold and the pool of tyrosine-containing molecules decreases by an equivalent amount.
在新生大鼠的大脑中，约一半的微管蛋白分子在翻译后通过在α链的羧基末端添加一种芳香族氨基酸而被修饰。在添加的残基中，96%是酪氨酸，4%是苯丙氨酸。诱导高苯丙氨酸血症后，含有羧基末端苯丙氨酸的微管蛋白分子比例增加至八倍，而含酪氨酸分子的总量等量减少。
