抗胰岛素血清和四氧嘧啶糖尿病对泌乳大鼠乳腺中己糖激酶分布及多种形式的影响。
The effect of anti-insulin serum and alloxan-diabetes on the distribution and multiple forms of hexokinase in lactating rat mammary gland.
作者信息
Walters E, McLean P
出版信息
Biochem J. 1968 Oct;109(5):737-41. doi: 10.1042/bj1090737.
Abstract
- The distribution and multiple forms of hexokinase activity in lactating rat mammary gland were investigated in alloxan-diabetic rats and in rats treated with anti-insulin serum. It was found that 46% of the total hexokinase of mammary-gland tissue from control rats was in the particulate fraction, but this percentage was decreased in the alloxan-diabetic rats to 11% of the total hexokinase. The hexokinase activity of the soluble fraction was not significantly altered but there was a decrease in the type II/type I quotient. 2. The early changes that occurred on insulin deprivation were studied 1hr. after administration of anti-insulin serum to lactating rats, at which time the hexokinase bound to the particulate fraction had decreased to 11% of the control value and that in the soluble fraction had increased by approx. 50%. The hexokinase type II/type I quotient in the soluble fraction was significantly decreased. These results suggested that there was a release of particulate-bound hexokinase in rats treated with anti-insulin serum.
摘要
- 研究了四氧嘧啶糖尿病大鼠和抗胰岛素血清处理的大鼠乳腺中己糖激酶活性的分布及多种形式。发现对照大鼠乳腺组织中总己糖激酶的46%存在于颗粒部分，但在四氧嘧啶糖尿病大鼠中，这一百分比降至总己糖激酶的11%。可溶性部分的己糖激酶活性无显著改变，但II型/I型比值降低。2. 在给哺乳期大鼠注射抗胰岛素血清1小时后，研究了胰岛素缺乏时发生的早期变化，此时与颗粒部分结合的己糖激酶已降至对照值的11%，而可溶性部分的己糖激酶增加了约50%。可溶性部分的己糖激酶II型/I型比值显著降低。这些结果表明，抗胰岛素血清处理的大鼠中存在颗粒结合的己糖激酶释放。
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本文引用的文献
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Effect of alloxan-diabetes on multiple forms of hexokinase in adipose tissue and lung.醛糖糖尿病对脂肪组织和肺中多种形式己糖激酶的影响。
Biochem J. 1967 Dec;105(3):1301-5. doi: 10.1042/bj1051301.
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