Duncan P M
Pharmacol Biochem Behav. 1979 Oct;11(4):377-81. doi: 10.1016/0091-3057(79)90110-2.
Rats which were subjected to aversive Pavlovian conditioning while in a state of ethanol-produced intoxication showed significantly less conditioned suppression of water drinking in the non-drugged state only if the external stimulus situation was also changed between conditioning and testing. This interaction between internal and external stimulus change supports a generalization-decrement explanation of drug-produced dissociation of memory. The number of conditioning trials was also manipulated, but this variable had no significant effect on the conditioned responses. In a second experiment, ethanol injections were given again shortly before testing. This treatment caused a normal degree of conditioned drinking suppression in rats conditioned in the ethanol state, indicating that state-dependent learning was responsible for the conditioned response deficit seen in the first experiment. The dissociation was asymmetrical since rats injected with ethanol before testing only showed a high degree of conditioned suppression.
处于乙醇所致中毒状态下接受厌恶性巴甫洛夫条件反射的大鼠，只有在条件反射和测试之间外部刺激情境也发生改变时，才会在非用药状态下表现出显著较少的条件性饮水抑制。内部和外部刺激变化之间的这种相互作用支持了对药物引起的记忆解离的泛化-递减解释。条件反射试验的次数也进行了操控，但该变量对条件反应没有显著影响。在第二个实验中，在测试前不久再次注射乙醇。这种处理在处于乙醇状态下进行条件反射的大鼠中引起了正常程度的条件性饮水抑制，表明状态依赖性学习是第一个实验中所见条件反应缺陷的原因。这种解离是不对称的，因为在测试前注射乙醇的大鼠仅表现出高度的条件抑制。
