de Ridder G, Berrens L
Scand J Respir Dis. 1979 Oct;60(5):243-52.
Two laboratory techniques have been applied for the diagnosis and follow-up of pigeon breeders' disease, viz. detection of precipitins against specific antigens from pigeon droppings and assays of human haemolytic complement (huC) consumption by pigeon dropping antigens. A simple laboratory test of huC consumption by pigeon antigens is described, revealing high huC sensitivity in almost all sera of pigeon breeders with manifest or former disease. False-positive results were seldom observed. Discontinuation of antigen exposure and/or corticosteroid therapy had no effect on the huC consumption level in the test system, despite precipitin titres falling below the level of detection. Titration studies revealed an initial decrease of the huC-consuming serum factors, but titres settled at a definite constant level, even after antigen avoidance for many years. Combined application of both the precipitin test and the huC consumption test appears to be a good procedure for the laboratory diagnosis of pigeon breeders' disease.
两种实验室技术已应用于鸽饲养者病的诊断和随访，即检测针对鸽粪中特定抗原的沉淀素以及检测鸽粪抗原对人溶血补体（huC）的消耗情况。本文描述了一种简单的检测鸽抗原对huC消耗的实验室试验，结果显示，几乎所有患有现症或既往鸽饲养者病的血清中huC敏感性都很高。很少观察到假阳性结果。尽管沉淀素滴度降至检测水平以下，但停止抗原接触和/或皮质类固醇治疗对测试系统中的huC消耗水平没有影响。滴定研究显示，最初消耗huC的血清因子有所下降，但即使在避免接触抗原多年后，滴度仍稳定在一个确定的恒定水平。沉淀素试验和huC消耗试验联合应用似乎是鸽饲养者病实验室诊断的一个良好方法。
