Wieckiewicz J
J Hyg Epidemiol Microbiol Immunol. 1979;23(3):326-31.
The L-forms of the Klecha 155 strain were induced in vitro by methicillin. After reversion, the strains were tested for 19 biochemical features and for susceptibility to penicillin, ampicillin and methicillin. Two reverted strains were less virulent for mice than the parent strain. It is concluded that the decrease in virulence of reverted Staph. aureus strains is correlated with changes in the chemical structure and composition of the cell wall after reversion from the L-phase variants.
用甲氧西林在体外诱导Klecha 155菌株形成L型。回复突变后，对这些菌株进行了19项生化特征检测以及对青霉素、氨苄青霉素和甲氧西林的敏感性检测。有两个回复突变菌株对小鼠的毒力低于亲本菌株。得出的结论是，金黄色葡萄球菌回复突变菌株毒力的降低与从L型变体回复突变后细胞壁化学结构和组成的变化相关。
