大鼠中芥子酸及相关化合物的代谢
Metabolism of sinapic acid and related compounds in the rat.
作者信息
Griffiths L A
出版信息
Biochem J. 1969 Jul;113(4):603-9. doi: 10.1042/bj1130603.
Abstract
- Administration of sinapic acid to the rat results in the excretion of 3-hydroxy-5-methoxyphenylpropionic acid, dihydrosinapic acid, 3-hydroxy-5-methoxycinnamic acid and unchanged sinapic acid in the urine. The sinapic acid conjugate sinalbin is also catabolized to free sinapic acid and 3-hydroxy-5-methoxyphenylpropionic acid in the rat. 2. 3,4,5-Trimethoxycinnamic acid is metabolized in part to sinapic acid and 3-hydroxy-5-methoxyphenylpropionic acid. 3. 3,5-Dimethoxycinnamic acid is metabolized to 3-hydroxy-5-methoxycinnamic acid and 3-hydroxy-5-methoxyphenylpropionic acid. 4. The metabolic interrelationships of these compounds were studied by the administration of intermediates and a metabolic pathway is proposed. 5. The metabolism of the corresponding benzoic acids was studied, but these compounds and their metabolites were shown not to be intermediates or products of the metabolism of the related cinnamic acids.
摘要
- 给大鼠施用芥子酸后，尿中会排出3-羟基-5-甲氧基苯丙酸、二氢芥子酸、3-羟基-5-甲氧基肉桂酸以及未变化的芥子酸。芥子酸共轭物白芥子硫苷在大鼠体内也会分解为游离的芥子酸和3-羟基-5-甲氧基苯丙酸。2. 3,4,5-三甲氧基肉桂酸部分代谢为芥子酸和3-羟基-5-甲氧基苯丙酸。3. 3,5-二甲氧基肉桂酸代谢为3-羟基-5-甲氧基肉桂酸和3-羟基-5-甲氧基苯丙酸。4. 通过施用中间体研究了这些化合物的代谢相互关系，并提出了一条代谢途径。5. 对相应苯甲酸的代谢进行了研究，但这些化合物及其代谢产物并非相关肉桂酸代谢的中间体或产物。
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