Zwoliński J, Buczko W
Pol J Pharmacol Pharm. 1977 May-Jun;29(3):313-9.
Fibrinogen degradation products (FDP) in a dose dependent manner potentiated the action of amphetamine in the tests for locomotor activity (Knoll's motimeter) and stereotypy. They also antagonized the haloperidol-induced catalepsy. FDP increased the level of amphetamine 90 min after the drug administration, and depressed it 120 min after the treatment. FDP slightly depressed the level of dopamine, and increased that of homovanillic acid in the striatum. They also potentiated the accumulation of noradrenaline in the hippocampus, produced by amphetamine, but did not affect the concentrations of dopamine and serotonin. It is suggested that the change in action of amphetamine under the influence of FDP depends on the direct effect of the peptides on amphetamine level in the brain, and on the level of some neuromediators.
在运动活性测试（诺尔运动计）和刻板行为测试中，纤维蛋白原降解产物（FDP）以剂量依赖的方式增强了苯丙胺的作用。它们还拮抗了氟哌啶醇诱导的僵住症。FDP在给药后90分钟增加了苯丙胺水平，而在治疗后120分钟降低了该水平。FDP轻微降低了纹状体中多巴胺水平，并增加了高香草酸水平。它们还增强了苯丙胺引起的海马中去甲肾上腺素的积累，但不影响多巴胺和血清素的浓度。提示在FDP影响下苯丙胺作用的变化取决于这些肽对脑内苯丙胺水平以及某些神经介质水平的直接作用。
