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Irreversible enzyme inhibitors. CXLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[p-(p-fluorosulfonylphenylureidomethyl)phenyl]-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine.

作者信息

Baker B R, Lourens G J

出版信息

J Med Chem. 1969 Jan;12(1):101-4. doi: 10.1021/jm00301a026.

DOI:10.1021/jm00301a026
PMID:5763002
Abstract
摘要

相似文献

1
Irreversible enzyme inhibitors. CXLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[p-(p-fluorosulfonylphenylureidomethyl)phenyl]-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine.不可逆酶抑制剂。CXLI。源自1-[对-(对-氟磺酰基苯基脲基甲基)苯基]-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪的二氢叶酸还原酶活性位点定向不可逆抑制剂。
J Med Chem. 1969 Jan;12(1):101-4. doi: 10.1021/jm00301a026.
2
Irreversible enzyme inhibitors. CXL. Active-site-directed irreversible inhibitors derived from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine.
J Med Chem. 1969 Jan;12(1):95-101. doi: 10.1021/jm00301a025.
3
Irreversible enzyme inhibitors. 143. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenoxypropyl)-2,4-diamino-6-methylpyrimidine with a terminal sulfonyl fluoride.
J Med Chem. 1969 Jan;12(1):108-11. doi: 10.1021/jm00301a028.
4
Irreversible enzyme inhibitors. CXLII. Further studies on active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-Aminophenoxypropyl)-2,4,6-triaminopyrimidine bearing a terminal sulfonyl fluoride.
J Med Chem. 1969 Jan;12(1):104-7. doi: 10.1021/jm00301a027.
5
Irreversible enzyme inhibitors. CXXXIX. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. VI. Further studies on effects of substitution on the propionamide bridge on isozyme specificity.
J Med Chem. 1969 Jan;12(1):92-4. doi: 10.1021/jm00301a024.
6
Irreversible enzyme inhibitors. 133. Studies on differential irreversible inhibition of dihydrofolic reductase from three strains of L1210 leukemia, liver, spleen, and intestine of the mouse.不可逆酶抑制剂。133. 关于对来自小鼠的三株L1210白血病细胞以及肝脏、脾脏和肠道中二氢叶酸还原酶的差异性不可逆抑制的研究。
J Med Chem. 1969 Jan;12(1):67-73. doi: 10.1021/jm00301a018.
7
Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity.不可逆酶抑制剂。CXXXVI。2,4-二氨基-5-(3,4-二氯苯基)-6-[对-(间-氟磺酰基苯甲酰胺基)苯氧基甲基]嘧啶，一种二氢叶酸还原酶的活性位点导向不可逆抑制剂。结构对同工酶特异性的影响。
J Med Chem. 1969 Jan;12(1):82-5.
8
Irreversible enzyme inhibitors. CXXXVII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenoxymethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine bearing a terminal sulfonyl fluoride.
J Med Chem. 1969 Jan;12(1):86-8. doi: 10.1021/jm00301a022.
9
Irreversible enzyme inhibitors. CXII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine substituted with a terminal sulfonyl fluoride. II.不可逆酶抑制剂。CXII。源自4,6-二氨基-1,2-二氢-2,2-二甲基-1-苯基-s-三嗪并被末端磺酰氟取代的二氢叶酸还原酶的活性位点导向不可逆抑制剂。II。
J Med Chem. 1968 Jan;11(1):38-41. doi: 10.1021/jm00307a007.
10
Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenz amido) phenoxymethyl] pyrimidine, an active-site-directed irreverisible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity.不可逆酶抑制剂。CXXXVI。2,4-二氨基-5-（3,4-二氯苯基）-6-[对-（间-氟磺酰基苯甲酰胺基）苯氧基甲基]嘧啶，一种二氢叶酸还原酶的活性位点导向不可逆抑制剂。结构对同工酶特异性的影响。
J Med Chem. 1969 Jan;12(1):82-5.