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Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenz amido) phenoxymethyl] pyrimidine, an active-site-directed irreverisible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity.

作者信息

Baker B R, Vermeulen N M

出版信息

J Med Chem. 1969 Jan;12(1):82-5.

PMID:5777842
Abstract
摘要

相似文献

1
Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenz amido) phenoxymethyl] pyrimidine, an active-site-directed irreverisible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity.不可逆酶抑制剂。CXXXVI。2,4-二氨基-5-（3,4-二氯苯基）-6-[对-（间-氟磺酰基苯甲酰胺基）苯氧基甲基]嘧啶，一种二氢叶酸还原酶的活性位点导向不可逆抑制剂。结构对同工酶特异性的影响。
J Med Chem. 1969 Jan;12(1):82-5.
2
Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity.不可逆酶抑制剂。CXXXVI。2,4-二氨基-5-(3,4-二氯苯基)-6-[对-(间-氟磺酰基苯甲酰胺基)苯氧基甲基]嘧啶，一种二氢叶酸还原酶的活性位点导向不可逆抑制剂。结构对同工酶特异性的影响。
J Med Chem. 1969 Jan;12(1):82-5.
3
Irreversible enzyme inhibitors. CXXXVII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenoxymethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine bearing a terminal sulfonyl fluoride.
J Med Chem. 1969 Jan;12(1):86-8. doi: 10.1021/jm00301a022.
4
Irreversible enzyme inhibitors. CXXXIV. Effect of ring substitution on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonyl-phenylureido)phenoxymethyl]pyrimidine.不可逆酶抑制剂。CXXXIV. 环取代对2,4-二氨基-5-(3,4-二氯苯基)-6-[对-(间-氟磺酰基-苯脲基)苯氧基甲基]嘧啶对L1210小鼠白血病和肝脏二氢叶酸还原酶选择性不可逆抑制作用的影响。
J Med Chem. 1969 Jan;12(1):74-8. doi: 10.1021/jm00301a019.
5
Irreversible enzyme inhibitors. 143. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenoxypropyl)-2,4-diamino-6-methylpyrimidine with a terminal sulfonyl fluoride.
J Med Chem. 1969 Jan;12(1):108-11. doi: 10.1021/jm00301a028.
6
Irreversible enzyme inhibitors. CXXXV. Effect of ring substitution on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(p-fluorosulfonyl-phenylureido)phenoxymethyl]pyrimidine.不可逆酶抑制剂。CXXXV. 环取代对2,4-二氨基-5-(3,4-二氯苯基)-6-[对-(对-氟磺酰基苯脲基)苯氧基甲基]嘧啶对L1210小鼠白血病和肝脏二氢叶酸还原酶的选择性不可逆抑制作用的影响。
J Med Chem. 1969 Jan;12(1):79-81. doi: 10.1021/jm00301a020.
7
Irreversible enzyme inhibitors. 138. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenethyl)-- 2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with a terminal sulfonyl fluoride.
J Med Chem. 1969 Jan;12(1):89-91. doi: 10.1021/jm00301a023.
8
Irreversible enzyme inhibitors. CXLII. Further studies on active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-Aminophenoxypropyl)-2,4,6-triaminopyrimidine bearing a terminal sulfonyl fluoride.
J Med Chem. 1969 Jan;12(1):104-7. doi: 10.1021/jm00301a027.
9
Irreversible enzyme inhibitors. 133. Studies on differential irreversible inhibition of dihydrofolic reductase from three strains of L1210 leukemia, liver, spleen, and intestine of the mouse.不可逆酶抑制剂。133. 关于对来自小鼠的三株L1210白血病细胞以及肝脏、脾脏和肠道中二氢叶酸还原酶的差异性不可逆抑制的研究。
J Med Chem. 1969 Jan;12(1):67-73. doi: 10.1021/jm00301a018.
10
Irreversible enzyme inhibitors. CXLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[p-(p-fluorosulfonylphenylureidomethyl)phenyl]-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine.不可逆酶抑制剂。CXLI。源自1-[对-(对-氟磺酰基苯基脲基甲基)苯基]-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪的二氢叶酸还原酶活性位点定向不可逆抑制剂。
J Med Chem. 1969 Jan;12(1):101-4. doi: 10.1021/jm00301a026.