Lie T S, Ebata H, Holst A, Nakano H, Kim Y Z
Res Exp Med (Berl). 1975 Jul 14;165(2):175-9. doi: 10.1007/BF01854844.
49 kidneys of male LBNF1-rats were transplanted into male Lewis-rats. BN-rats were used as a source of antigen. Control animals survived 16.1 +/- 1.8 days. 5 recipients were preteated with donorspecific living cells, 7 with semisoluble and 5 with low dosage of soluble antigen. The living cell-pretreatment showed the best effect for the active enhancement, the soluble antigen the least. The pretreatment with 6 mg protein/kg bw. caused the sensibilization of recipients. At the time of transplantation lymphcytotoxic antibody titers were detected in all recipients with pretreatment of living cells, but no titer in other groups. Renal allografts with elevated postopertive titer were rejected rapidly.
将49只雄性LBNF1大鼠的肾脏移植到雄性Lewis大鼠体内。BN大鼠作为抗原来源。对照动物存活16.1±1.8天。5只受体用供体特异性活细胞预处理，7只用半溶性抗原预处理，5只用低剂量可溶性抗原预处理。活细胞预处理对活性增强效果最佳，可溶性抗原效果最差。用6mg蛋白质/千克体重进行预处理导致受体致敏。在移植时，所有接受活细胞预处理的受体中均检测到淋巴细胞毒性抗体滴度，而其他组未检测到滴度。术后滴度升高的肾同种异体移植物被迅速排斥。
