鱿鱼轴突中负电导物理基础的一种研究方法。
An approach to the physical basis of negative conductance in the squid axon.
作者信息
Agin D
出版信息
Biophys J. 1969 Feb;9(2):209-21. doi: 10.1016/S0006-3495(69)86380-0.
Abstract
In considering the problem of steady-state negative conductance in the squid axon from the standpoint of electrodiffusion, the following assumptions produce results which are in reasonable agreement with experimental observations: (1) The major ion distributions are not significantly perturbed by current flows (2) The electric field in the membrane is essentially uniform. (3) The membrane has certain properties appropriate to solids, particularly with respect to chemical potentials. (4) Na(+) and K(+) move according to a single-file interstitialcy migration mechanism and independently of each other. (5) The interaction energy of Na(+) with membrane sites is about 1.4 times that for K(+). Assumptions 1 and 2 are sufficient for the appearance of a negative conductance. Experimental test of the theory is possible and is specifically suggested.
摘要
从电扩散的角度考虑鱿鱼轴突中稳态负电导的问题时，以下假设得出的结果与实验观察结果合理相符：（1）主要离子分布不会因电流流动而受到显著扰动；（2）膜中的电场基本均匀；（3）膜具有某些适合固体的特性，特别是在化学势方面；（4）Na(+)和K(+)根据单文件间隙迁移机制移动且彼此独立；（5）Na(+)与膜位点的相互作用能约为K(+)的1.4倍。假设1和2足以产生负电导。该理论的实验验证是可行的，特此提出。
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本文引用的文献
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