Bengtsson S, Lindholm C E, Osterman K
Scand J Respir Dis. 1979 Oct;60(5):225-9.
Concentrations of azidocillin in serum and tracheobronchial secretions were followed in 20 patients after an oral dose of 0.75 g of the drug. Serum concentrations were followed for 4 h and the concentration in tracheobronchial secretion was determined in samples taken through a fibreoptic bronchoscope 1--2 h after administration. The concentration in secretions varied between hardly measurable levels and 1.1 micrograms/ml. No correlation between levels in serum and tracheobronchial secretion was found. A slight tendency to higher secretion levels was found when the bronchoscopy showed signs of tracheobronchitis.
对20例口服0.75 g叠氮西林的患者，监测其血清和气管支气管分泌物中的药物浓度。监测血清浓度4小时，并在给药后1 - 2小时通过纤维支气管镜采集样本，测定气管支气管分泌物中的浓度。分泌物中的浓度在几乎无法测量的水平至1.1微克/毫升之间变化。未发现血清和气管支气管分泌物中的浓度之间存在相关性。当支气管镜检查显示气管支气管炎迹象时，发现分泌物水平有轻微升高的趋势。
