蛋白质缺乏的大鼠中，二甲基亚硝胺导致肾癌发生增加。
Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.
作者信息
McLean A E, Magee P N
出版信息
Br J Exp Pathol. 1970 Dec;51(6):587-90.
Abstract
Protein deficiency at the time of dosage protects rats against the acute lethal effects of dimethyl nitrosamine, but increases the late carcinogenic actions of the poison. A single dose of 60 mg. dimethyl nitrosamine/kg. leads to the development of kidney cancers in all the surviving rats after 8-11 months. 40 mg./kg. produces tumours in over half of the survivors in 14 months. Induction of liver microsomal hydroxylation enzymes with phenobarbitone does not prevent the carcinogenic effects of dimethyl nitrosamine.
摘要
给药时蛋白质缺乏可保护大鼠免受二甲基亚硝胺的急性致死作用，但会增强该毒物的晚期致癌作用。单次给予60毫克二甲基亚硝胺/千克，8至11个月后所有存活大鼠都会发生肾癌。给予40毫克/千克，14个月后超过半数存活大鼠会产生肿瘤。用苯巴比妥诱导肝微粒体羟化酶并不能预防二甲基亚硝胺的致癌作用。
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