Margalit R, Gidron E, Shalitin Y
Thromb Haemost. 1977 Apr 30;37(2):210-5.
The term "effective activator" of plasminogen is proposed, to denote the resultant of activator-antiactivator interaction, and a method for the determination of the level of these activators is described. By adding axcess plasminogen to the euglobulin fraction of plasma the influence of the level of endogenous plasminogen and of the antiplasmin is eliminated. It is shown that the level of fibrinogen has very little bearing on the results. An effective activator unit is defined as equal to 1 CTA unit of urokinase activity on a fibrinogen-plasminogen substrate.
提出了“纤溶酶原有效激活剂”这一术语，以表示激活剂 - 抗激活剂相互作用的结果，并描述了一种测定这些激活剂水平的方法。通过向血浆的优球蛋白组分中加入过量的纤溶酶原，消除了内源性纤溶酶原水平和抗纤溶酶的影响。结果表明，纤维蛋白原水平对结果影响很小。一个有效激活剂单位定义为在纤维蛋白原 - 纤溶酶原底物上相当于1个尿激酶活性CTA单位。
