Bengmark S, Elmér O, Göransson G
Eur Surg Res. 1980;12(5):333-42. doi: 10.1159/000128139.
Earlier in vitro experiments have shown microaggregate formation in pig and rabbit blood after addition of ethanol. In this study ethanol was given to pigs resulting in ethanol concentrations of 30-40 mmol/l 2-4 h after administration. As would be expected ethanol concentration was higher in the portal vein than in the hepatic vein, caval vein or aorta. Microaggregates in circulating blood were measured with screen filtration pressure (SFP). SFP rose to more than double the initial value in ethanol-intoxicated pigs whereas it remained unchanged in controls. The ethanol-intoxicated pigs developed hemoconcentration and metabolic acidosis. Our results indicate that microaggregates probably made up of aggregated platelets are formed in pig blood during acute ethanol intoxication.
早期的体外实验表明，添加乙醇后猪和兔的血液中会形成微聚集体。在本研究中，给猪注射乙醇，给药后2 - 4小时乙醇浓度达到30 - 40 mmol/l。正如预期的那样，门静脉中的乙醇浓度高于肝静脉、腔静脉或主动脉中的乙醇浓度。用筛滤压（SFP）测量循环血液中的微聚集体。在乙醇中毒的猪中，SFP升至初始值的两倍以上，而在对照组中则保持不变。乙醇中毒的猪出现了血液浓缩和代谢性酸中毒。我们的结果表明，急性乙醇中毒期间猪血液中可能形成了由聚集血小板组成的微聚集体。
