Weiss M, Förster W
Z Gesamte Inn Med. 1976 Sep 1;31(17):673-9.
A survey is given on the most important theoretical methods which are necessary for the analysis of pharmacokinetic data in clinic and experiment. According to their importance in practice the stress is on the description of the analysis of linear pharmacokinetic systems. Issuing from the general multicompartment theory the one- and two-compartment models important in clinic are dealt with more in detail. The problems of the model identification in models with three and more compartments are explained. With the help of the example of the one-compartment model the authors deal with the problems of the non-linear kinetics, which may appear in drugs with high plasma concentration. Summarizing are finally some hints given at the use of these theoretical methods in practice.
本文综述了临床和实验中药代动力学数据分析所需的最重要理论方法。根据它们在实践中的重要性，重点描述了线性药代动力学系统的分析。从一般的多室理论出发，更详细地讨论了临床中重要的一室和二室模型。解释了三室及更多室模型中的模型识别问题。借助一室模型的例子，作者探讨了高血浆浓度药物中可能出现的非线性动力学问题。最后总结了这些理论方法在实践中的一些应用提示。
