Britton B J, Giddings J C, Brooks L, Bloom A L
Thromb Haemost. 1977 Jun 30;37(3):527-34.
The role of catecholamines in the activation of coagulation and fibrinolysis following surgery remains controversial. In this study 5 dogs were infused with 1,2,3,6,9 and 12 microgram kg-1 min-1 of adrenaline at twice weekly intervals and were then reexposed to 3 microgram kg-1 min-1. Pulse rate and factor VIII increased after infusion of 1,2 and 3 microgram kg-1 min-1 but thereafter there was a diminished response and no response on reexposure to 3 microgram kg-1 min-1 although this was not significant in the case of pulse rate. Euglobulin lysis time shortened after each infusion of adrenaline and showed no development of tolerance. A control series of dogs infused with saline showed no similar changes. Both groups of animals were then bled to a blood pressure of 60 mm Hg for 60 minutes. Pulse rate and factor VIII did not change but euglobulin lysis time shortened in both groups. The results suggest that the activation pathways for changes in factor VIII and euglobulin lysis time induced by adrenaline are separate.
儿茶酚胺在术后凝血和纤维蛋白溶解激活过程中的作用仍存在争议。在本研究中，5只狗每隔一周接受一次肾上腺素输注，剂量分别为1、2、3、6、9和12微克/千克/分钟，之后再次接受3微克/千克/分钟的输注。输注1、2和3微克/千克/分钟后，心率和因子VIII升高，但此后反应减弱，再次接受3微克/千克/分钟输注时无反应，尽管心率方面不显著。每次输注肾上腺素后优球蛋白溶解时间缩短，且未出现耐受性。输注生理盐水的对照组狗未出现类似变化。然后两组动物均被放血至血压为60毫米汞柱并持续60分钟。心率和因子VIII未改变，但两组优球蛋白溶解时间均缩短。结果表明，肾上腺素诱导的因子VIII和优球蛋白溶解时间变化的激活途径是分开的。
