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Cyto-enetic investigations of mammals. Comparison of the genetic activity of cytostatics in mammals.

作者信息

Röhrborn G, Basler A

出版信息

Arch Toxicol. 1977 Sep 21;38(1-2):35-43. doi: 10.1007/BF00293661.

DOI:10.1007/BF00293661
PMID:578713
Abstract

Mutagenicity tests have been performed with CP, IP and TP. There is an increase of mutagenic activity from TP to IP to CP 8 h after the second intraperitoneal application. This has been confirmed by analysis of bone marrow chromosomes of mice, rats and Chinese hamsters. The maximum mutagenic activity of all three cytostatics was found 12 h after the second injection. Thereafter the aberration rate induced by CP decreased quickly. The inactivation of IP and TP and the elimination of chromosome aberrations was delayed. Dose-effect-relationships of CP in Chinese hamsters were investigated using the micronucleaus test and analysis of bone marrow chromosomes. Correlations between the two test systems could be demonstrated. Five applications of CP led to a drastic increase of chromosome aberrations in bone marrow of Chinese hamsters. In spermatogonia, on the other hand, no significant increase was detectable. These differences are being discussed.

摘要

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本文引用的文献

1
Chromosome studies on bone marrow from Chinese hamsters treated with benzodiazepine tranquillizers and cyclophosphamide.对用苯二氮䓬类镇静剂和环磷酰胺处理过的中国仓鼠的骨髓进行的染色体研究。
Mutat Res. 1969 Jan-Feb;7(1):99-108. doi: 10.1016/0027-5107(69)90053-0.
2
An air-drying method for preparing metaphase chromosomes from the spermatogonial cells of rats and mice.一种从大鼠和小鼠精原细胞制备中期染色体的空气干燥法。
Mutat Res. 1971 Sep;13(1):85-8. doi: 10.1016/0027-5107(71)90128-x.
3
Method for testing mutagenic effects of chemicals on spermatogonia of the Chinese hamster: results obtained with cyclophosphamide, saccharin, and cyclamate.
检测化学物质对中国仓鼠精原细胞诱变作用的方法：环磷酰胺、糖精和甜蜜素的实验结果
Arzneimittelforschung. 1975;25(12):1889-96.