血清中异烟酰肼消失速率的表型鉴别
The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum.
作者信息
Scott E M, Wright R C, Weaver D D
出版信息
J Clin Invest. 1969 Jul;48(7):1173-6. doi: 10.1172/JCI106081.
Abstract
Expression of the rate of inactivation of isonicotinoyl hydrazide (INH) as a first-order constant gave better discrimination of slow and rapid inactivators than did the level of INH at the end of 6 hr. The most probable division point between the two classes was at k = 0.130. Rate of inactivation by obligatory heterozygotes was determined. Such heterozygotes could not be adequately differentiated from homozygous rapid inactivators. The gene frequency for slow inactivation was 0.46 +/-0.04 in Alaskan Eskimos and 0.62+/-0.06 in Athabaskan Indians.
摘要
将异烟酰肼（INH）失活速率表示为一级常数，与6小时末INH的水平相比，能更好地区分慢失活者和快失活者。两类之间最可能的分界点是k = 0.130。测定了 obligatory 杂合子的失活速率。这类杂合子无法与纯合快失活者充分区分开来。阿拉斯加爱斯基摩人中慢失活的基因频率为0.46±0.04，阿萨巴斯卡印第安人中为0.62±0.06。
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