气胸、呼吸急促和肺血管充血时肺刺激感受器的活动。
The activity of lung irritant receptors during pneumothorax, hyperpnoea and pulmonary vascular congestion.
作者信息
Sellick H, Widdicombe J G
出版信息
J Physiol. 1969 Aug;203(2):359-81. doi: 10.1113/jphysiol.1969.sp008868.
Abstract
- The activity of lung irritant receptors during pneumothorax, hyperpnoea and pulmonary congestion has been studied by recording from single vagal nerve fibres from the receptors in rabbits.2. The receptors were stimulated during induction and during removal of pneumothorax.3. Pneumothorax caused a greater depression of minute volume in bilaterally vagotomized rabbits, compared with those with intact vagus nerves.4. Hyperpnoea due to breathing through an added dead space increased the discharge of the receptors. Experiments on paralysed and artificially ventilated rabbits showed that this was not a direct action of the asphyxial changes in blood gas tensions.5. Pulmonary congestion, induced by inflating a balloon in the left atrium, stimulated the receptors in paralysed artificially ventilated rabbits.6. The evidence that the receptors cause vagal reflex hyperpnoea and bronchoconstriction is discussed, together with their role in the reflex ventilatory and bronchomotor changes in the conditions studied.
摘要
通过记录兔肺刺激性感受器的单根迷走神经纤维活动，研究了气胸、呼吸急促和肺充血期间肺刺激性感受器的活动情况。
在诱导气胸和去除气胸的过程中对感受器进行刺激。
与迷走神经完整的兔子相比，双侧迷走神经切断的兔子在气胸时每分通气量的降低更为明显。
通过增加无效腔进行呼吸引起的呼吸急促增加了感受器的放电。对麻痹并进行人工通气的兔子所做的实验表明，这并非血气张力窒息性变化的直接作用。
通过向左心房内充气诱导肺充血，刺激了麻痹并进行人工通气的兔子的感受器。
讨论了感受器引起迷走神经反射性呼吸急促和支气管收缩的证据，以及它们在所研究的情况下反射性通气和支气管运动变化中的作用。
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