Preston F E, Emmanuel I G, Winfield D A, Malia R G
Br Med J. 1974 Aug 31;3(5930):548-52. doi: 10.1136/bmj.3.5930.548.
Six patients are described in whom gangrene of one or more toes occurred as the presenting feature of essential thrombocythaemia. Spontaneous platelet aggregation was observed in platelet-rich plasma from four patients and platelet aggregation after the addition of adenosine diphosphate and collagen was highly abnormal in samples from all six. All of the patients described dramatic relief of pain within six hours of ingestion of aspirin and this coincided with disappearance of the spontaneous platelet aggregation and collagen-induced platelet aggregation. Treatment with phosphorus-32 corrected the platelet count and there were no further recurrences of peripheral vascular disease. Platelet function tests performed at the time all gave normal results. It is concluded that essential thrombocythaemia is an important and treatable cause of peripheral vascular disease.
本文描述了6例患者，他们以一个或多个足趾坏疽作为原发性血小板增多症的首发特征。在4例患者富含血小板的血浆中观察到自发血小板聚集，所有6例患者样本中添加二磷酸腺苷和胶原后血小板聚集高度异常。所有患者在服用阿司匹林6小时内疼痛显著缓解，这与自发血小板聚集和胶原诱导的血小板聚集消失相一致。用磷-32治疗使血小板计数恢复正常，周围血管疾病未再复发。当时进行的血小板功能测试均给出正常结果。结论是原发性血小板增多症是周围血管疾病的一个重要且可治疗的病因。
