Paulini K, Bock G, Sonntag W
Arzneimittelforschung. 1977;27(11):2051-5.
The influence of D-penicillamine (DPA) administration on a defined acute exudative inflammation in a model granuloma was investigated in a short-term experiment. The results indicate that DPA administration influences the metabolism of collagen but does not influence the proliferation behaviour of the fibroblasts. A significant increase in the number of fibroblasts can be explained in terms of an interaction of the loss of the soluble collagen with the number of fibroblasts necessary to maintain the total collagen level constant.
在一项短期实验中，研究了给予D-青霉胺（DPA）对模型肉芽肿中特定急性渗出性炎症的影响。结果表明，给予DPA会影响胶原蛋白的代谢，但不影响成纤维细胞的增殖行为。成纤维细胞数量的显著增加可以用可溶性胶原蛋白的损失与维持总胶原蛋白水平恒定所需的成纤维细胞数量之间的相互作用来解释。
