Brehm H, Albrecht I
Fertil Steril. 1978 Feb;29(2):144-7. doi: 10.1016/s0015-0282(16)43090-6.
A new vaginal contraceptive method that offers the ease of use with none of the potentially harmful physiologic effects of hormonal contraception was subjected to direct in vivo tests of its efficacy in immobilizing spermatozoa and preventing their entry into the cervical canal. The new contraceptive, a small avoid only 2.8 cm long and 1.4 cm wide, is easily inserted into the vagina without the need for special applicators. It offers protection through the delivery of a highly effective spermicide by the effervescent formation of foam that disperses over the uterine opening. In the trials, no motile spermatozoa could be found in any samples obtained from the vagina, the os externum, or the cervical canal immediately after intercouse protected with the new agent. In no case were any sperm, even immotile sperm, observed in the cervical canal. By contrast, examination of 30 samples obtained immediately after coitus protected with another contraceptive agent (used as a control) revealed motile spermatozao in the cervical canal in nine cases, and propulsive motility was seen on five occasions. The new contraceptive proved highly effective in preventing conception.
一种新型阴道避孕方法，使用方便且无激素避孕的潜在有害生理影响，该方法接受了直接的体内测试，以检验其使精子失去活力并防止其进入宫颈管的效果。这种新型避孕药是一个仅2.8厘米长、1.4厘米宽的小圆盘，无需特殊的施药器就能轻松插入阴道。它通过产生泡沫的方式释放高效杀精剂来提供保护，这些泡沫会分散在子宫开口处。在试验中，在使用这种新型药剂进行性交保护后立即从阴道、阴道口或宫颈管获取的任何样本中，均未发现有活动精子。在任何情况下，宫颈管内均未观察到任何精子，甚至是不活动的精子。相比之下，对使用另一种避孕药（用作对照）进行性交保护后立即获取的30个样本进行检查发现，9例宫颈管中有活动精子，5次观察到推进性运动。这种新型避孕药在预防怀孕方面被证明非常有效。
