Sangi-Haghpeykar H, Poindexter A N, Levine H
Baylor College of Medicine, Department of Ob/Gyn, Houston, TX 77030, USA.
Contraception. 1996 Jun;53(6):353-6. doi: 10.1016/0010-7824(96)00084-4.
The present study was undertaken to evaluate the effectiveness of Advantage 24 to inhibit sperm transport and survival when applied at 24 hours, 12 hours, and 15-30 minutes prior to a single act of intercourse. Conceptrol, applied at 15-30 minutes before intercourse, was employed as the comparative spermicide. One-hundred-thirty-nine women, aged 22 to 45 years, were enrolled into the study and 111 completed the trial. The ability of the spermicides to immobilize sperm was assessed by postcoital testing (PCT) and by examining the proportion of sperm immobilization failure (SIF) rates. SIF was a postcoital test result with > or = 10 sperm with progressive motility (either sluggish or rapid) per x 400 power field. Conceptrol and Advantage 24 used at 15-30 minutes were similar with respect to their ability to inactivate sperm (0% and 2% SIF, respectively, p = 0.5). At longer intervals between spermicidal application and intercourse, less inhibition of sperm motility was noted (9% and 14% SIF for 12 and 24 hours, respectively). The present study indicates that Advantage 24 is an effective agent to immobilize sperm. The action of Advantage 24 may decrease if it is applied earlier than 15-30 minutes before intercourse.
本研究旨在评估Advantage 24在单次性交前24小时、12小时以及15 - 30分钟应用时抑制精子运输和存活的有效性。将性交前15 - 30分钟应用的Conceptrol作为对照杀精剂。139名年龄在22至45岁之间的女性参与了该研究，111名完成了试验。通过性交后测试（PCT）以及检查精子固定失败（SIF）率的比例来评估杀精剂使精子失去活力的能力。SIF是指在每400倍视野下有≥10条具有进行性运动（缓慢或快速）精子的性交后测试结果。性交前15 - 30分钟使用的Conceptrol和Advantage 24在使精子失活的能力方面相似（SIF分别为0%和2%，p = 0.5）。在杀精剂应用与性交之间的间隔时间更长时，观察到对精子活力的抑制作用较小（12小时和24小时的SIF分别为9%和14%）。本研究表明Advantage 24是一种使精子失去活力的有效制剂。如果在性交前早于15 - 30分钟应用，Advantage 24的作用可能会降低。
