胰岛素治疗的糖尿病患者中循环游离胰岛素与结合胰岛素、胰岛素抗体、胰岛素剂量及糖尿病控制之间的关系。

The relationship between circulating free and bound insulin, insulin antibodies, insulin dosage and diabetic control in insulin treated diabetics.

作者信息

Asplin C M, Hartog M, Goldie D J

出版信息

Acta Endocrinol (Copenh). 1978 Feb;87(2):330-8. doi: 10.1530/acta.0.0870330.

DOI:10.1530/acta.0.0870330

Abstract

Free and bound insulin concentrations, blood glucose and anti-insulin antibody binding characteristics have been determined in 100 insulin treated diabetics; medium serum free insulin was 11 mU/l when fasting and rose to 30 mU/l after the mid-day meal. Significant correlation between blood glucose and serum free (but not bound) insulin was found. No relationship between insulin antibodies and daily insulin dose or diabetic control were found, nor a relationship between free insulin and antibody characteristics.

摘要

对100名接受胰岛素治疗的糖尿病患者测定了游离胰岛素和结合胰岛素浓度、血糖及抗胰岛素抗体结合特性；空腹时血清游离胰岛素平均为11 mU/l，午餐后升至30 mU/l。发现血糖与血清游离（而非结合）胰岛素之间存在显著相关性。未发现胰岛素抗体与每日胰岛素剂量或糖尿病控制之间存在关联，也未发现游离胰岛素与抗体特性之间存在关联。