Klapdor R, Sepehr H
Arzneimittelforschung. 1978;28(1):46-8.
The influence of the spasmolytic drugs hyoscin-N-butylbromide (HBB, Buscopan) and Extractum opii (E. opii) on bile flow, bile salt and bilirubin excretion is investigated in the cholecystectomized, unanaesthetized pig and compared with the results after acute, quantitative interruption of the enterohepatic circulation (EHC) by biliary drainage. The results demonstrate that HBB and E. opii induce a significant decrease in bile flow and bile salt excretion. A further analysis suggests that this effect is due to an inhibition of intestinal motility and transit time, followed by a delay of the EHC of bile salts with a decrease in biliary bile salt excretion and bile salt dependent bile flow. The results point out a second mechanism that might be responsible for the effectiveness of spasmolytic drugs in the treatment of biliary colics: the lowering of intraluminal pressure by inhibition of bile salt dependent bile flow.
在胆囊切除且未麻醉的猪身上，研究了解痉药物丁溴东莨菪碱（HBB，解痉灵）和阿片提取物（E. opii）对胆汁流量、胆汁盐和胆红素排泄的影响，并与通过胆汁引流急性定量中断肠肝循环（EHC）后的结果进行比较。结果表明，HBB和E. opii可导致胆汁流量和胆汁盐排泄显著减少。进一步分析表明，这种作用是由于肠道运动和转运时间受到抑制，随后胆汁盐的肠肝循环延迟，胆汁中胆汁盐排泄减少以及胆汁盐依赖性胆汁流量降低。结果指出了解痉药物治疗胆绞痛有效性的另一种机制：通过抑制胆汁盐依赖性胆汁流量降低管腔内压力。
