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[环己醇系列一种新型镇痛药的精神效应研究。对曲马多可能的精神依赖性潜力的探讨(作者译)]

[Examination of psychic effects of a new analgesic agent of the cyclohexanols series. A contribution to a possible psychic dependence potential of tramadol (author's transl)].

作者信息

Huber H P

出版信息

Arzneimittelforschung. 1978;28(1a):189-91.

PMID:580217
Abstract

A double-blind trial was performed with 30 male students of the University of Düsseldorf. The volunteers were divided at random into two groups containing 15 subjects each. One group received 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (tramadol; Tramal), and the other placebo. The latter served as the controls. On three occasions at regular intervals in the course of one week the volunteers were questioned on the basis of Janke and Debus's "Eigenschaftswörterliste" (EWL) (attribution word list). The interviews were carried out 1 h after the injection (1 ampoule 100 mg i.m.). The results in the sense of any euphoretic or dysphoretic effects are discussed.

摘要

对杜塞尔多夫大学的30名男学生进行了一项双盲试验。志愿者被随机分为两组,每组15人。一组接受1-(间甲氧基苯基)-2-(二甲基氨基甲基)-环己醇(曲马多;奇曼丁),另一组接受安慰剂。后者作为对照组。在一周内每隔一段时间对志愿者进行三次询问,询问基于扬克和德布斯的“属性词表”(EWL)(属性词列表)。访谈在注射后1小时(1安瓿100毫克肌肉注射)进行。讨论了任何欣快或烦躁不安效应方面的结果。

相似文献

1
[Examination of psychic effects of a new analgesic agent of the cyclohexanols series. A contribution to a possible psychic dependence potential of tramadol (author's transl)].[环己醇系列一种新型镇痛药的精神效应研究。对曲马多可能的精神依赖性潜力的探讨(作者译)]
Arzneimittelforschung. 1978;28(1a):189-91.
2
[Algo-pupillometric investigation of the analgesic effect of tramadol (author's transl)].曲马多镇痛作用的瞳孔测量算法研究(作者译)
Arzneimittelforschung. 1978;28(1a):176-8.
3
[The effect of tramadol and other analgesics on the pain threshold in human dental pulp (author's transl)].曲马多及其他镇痛药对人牙髓疼痛阈值的影响(作者译)
Arzneimittelforschung. 1978;28(1a):181-3.
4
[Clinical trial of tramadol by means of the "paired card" system (author's transl)].曲马多采用“配对卡”系统的临床试验(作者译)
Arzneimittelforschung. 1978;28(1a):196-9.
5
[The effect of tramadol, a new analgesic, on respiration and cardiovascular function (author's transl)].新型镇痛药曲马多对呼吸及心血管功能的影响(作者译)
Arzneimittelforschung. 1978;28(1a):183-6.
6
Drug dependence potential of 1-(m-methoxyphenyl)-2-dimethylaminomethyl)-cyclohexan-1-ol hydrochloride (tramadol) tested in monkeys.1-(间甲氧基苯基)-2-(二甲基氨基甲基)-环己醇盐酸盐(曲马多)在猴子身上进行的药物依赖性潜力测试。
Arzneimittelforschung. 1978;28(1a):158-63.
7
[The effect of tramadol on psychic and psychomotor performance in man (author's transl)].曲马多对人体心理和精神运动能力的影响(作者译)
Arzneimittelforschung. 1978;28(1a):179-80.
8
Clinical investigation on the development of dependence during oral therapy with tramadol.曲马多口服治疗期间依赖性发展的临床研究。
Arzneimittelforschung. 1985;35(11):1742-4.
9
[The effect of tramadol in an open clinical trial (author's transl)].曲马多在一项开放性临床试验中的效果(作者译)
Arzneimittelforschung. 1978;28(1a):209-12.
10
[The effect of tramadol on the EEG and the electronystagmogram (author's transl)].曲马多对脑电图和眼震电图的影响(作者译)
Arzneimittelforschung. 1978;28(1a):187-9.

引用本文的文献

1
Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states.曲马多。对其药效学和药代动力学特性以及在急慢性疼痛状态下的治疗潜力的初步综述。
Drugs. 1993 Aug;46(2):313-40. doi: 10.2165/00003495-199346020-00008.
2
Chronic pain--challenge and response.慢性疼痛——挑战与应对
Drugs. 1994;47 Suppl 1:33-8. doi: 10.2165/00003495-199400471-00006.