Budd K
Bradford Royal Infirmary, Yorkshire, England.
Drugs. 1994;47 Suppl 1:33-8. doi: 10.2165/00003495-199400471-00006.
Tramadol is effective in treating both acute and chronic pain, exhibiting a potency equivalent to that of pethidine, and it has an acceptable adverse event profile. Whilst the most common adverse events are nausea, vomiting, drowsiness and dizziness, as would be expected from an opioid, there is a noticeable lack of respiratory depression. This latter property, together with its low potential for the development of tolerance and dependence, make tramadol a most interesting agent for clinical use. The studies reported in this article illustrate the beneficial and adverse effects of tramadol to enable the clinician to judge the value of this agent.
曲马多在治疗急性和慢性疼痛方面均有效，其效力与哌替啶相当，且具有可接受的不良事件谱。虽然最常见的不良事件是恶心、呕吐、嗜睡和头晕，这是阿片类药物常见的不良反应，但值得注意的是它没有明显的呼吸抑制作用。后一特性，再加上其产生耐受性和依赖性的可能性较低，使得曲马多成为临床上一种非常有吸引力的药物。本文报道的研究阐述了曲马多的有益和不良作用，以便临床医生判断该药物的价值。
